Pathological Changes in the Parahippocampal Region in Select Non‐Alzheimer's Dementias
Identifieur interne : 001B88 ( Main/Exploration ); précédent : 001B87; suivant : 001B89Pathological Changes in the Parahippocampal Region in Select Non‐Alzheimer's Dementias
Auteurs : Heiko Braak [Allemagne] ; Kelly Del Tredici [Allemagne] ; Jürgen Bohl [Allemagne] ; Hansjürgen Bratzke [Allemagne] ; Eva Braak [Allemagne]Source :
- Annals of the New York Academy of SciencesTHE PARAHIPPOCAMPAL REGION: IMPLICATIONS FOR NEUROLOGICAL AND PSYCHIATRIC DISEASES [ 0077-8923 ] ; 2000-06.
Abstract
Abstract: The transentorhinal and entorhinal regions of the human brain extend over the ambient gyrus and anterior portions of the parahippocampal gyrus. They are important components of the limbic loop which receives its major afferents from the neocortical sensory association areas and generates powerful efferent projections both directly and via intermediary relay stations to the prefrontal cortex. The bilateral structural preservation of limbic loop components is a prerequisite for the maintenance of intact memory functions. In progressive neurodegenerative diseases, such as Alzheimer's disease, argyrophilic grain disease, Pick's disease, idiopathic Parkinson syndrome, and Huntington's disease, the transentorhinal and entorhinal regions are particularly susceptible to severe pathological changes. The transentorhinal region typically registers the initial alterations and becomes the most severely involved. From this transitional region of the mesocortex, the alterations usually invade with decreasing severity both the entorhinal region and temporal proneocortex. Each type of lesion that develops in the above‐mentioned neurode‐generative disorders hampers or even interrupts data‐transport from the sensory neocortex to the prefrontal neocortex, thereby contributing to the insidious development of progressive changes in personality, cognitive decline, and, ultimately, dementia.
Url:
DOI: 10.1111/j.1749-6632.2000.tb06729.x
Affiliations:
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They are important components of the limbic loop which receives its major afferents from the neocortical sensory association areas and generates powerful efferent projections both directly and via intermediary relay stations to the prefrontal cortex. The bilateral structural preservation of limbic loop components is a prerequisite for the maintenance of intact memory functions. In progressive neurodegenerative diseases, such as Alzheimer's disease, argyrophilic grain disease, Pick's disease, idiopathic Parkinson syndrome, and Huntington's disease, the transentorhinal and entorhinal regions are particularly susceptible to severe pathological changes. The transentorhinal region typically registers the initial alterations and becomes the most severely involved. From this transitional region of the mesocortex, the alterations usually invade with decreasing severity both the entorhinal region and temporal proneocortex. Each type of lesion that develops in the above‐mentioned neurode‐generative disorders hampers or even interrupts data‐transport from the sensory neocortex to the prefrontal neocortex, thereby contributing to the insidious development of progressive changes in personality, cognitive decline, and, ultimately, dementia.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Braak, Heiko" sort="Braak, Heiko" uniqKey="Braak H" first="Heiko" last="Braak">Heiko Braak</name></noRegion><name sortKey="Bohl, Jurgen" sort="Bohl, Jurgen" uniqKey="Bohl J" first="Jürgen" last="Bohl">Jürgen Bohl</name><name sortKey="Braak, Eva" sort="Braak, Eva" uniqKey="Braak E" first="Eva" last="Braak">Eva Braak</name><name sortKey="Bratzke, Hansjurgen" sort="Bratzke, Hansjurgen" uniqKey="Bratzke H" first="Hansjürgen" last="Bratzke">Hansjürgen Bratzke</name><name sortKey="Del Tredici, Kelly" sort="Del Tredici, Kelly" uniqKey="Del Tredici K" first="Kelly" last="Del Tredici">Kelly Del Tredici</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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